Week 2 of the college football schedule is here, and now it time to make our weekly picks against the spread. The noon kickoff between No. 1 Alabama and Texas is the premier matchup this weekend in terms of big-time brands, but there also a very important matchup taking place in the SEC between Florida and Kentucky. Let take a look at this week ATS college football picks and predictions. College football Week 2 picks, predictions against the spreadOdds according to SI SportsbookNo. 1 Alabama at TexasPoint spread: Alabama -20Alabama ATS: 1-0-0Texas ATS: 1-0-0What to expect: The first big national spotlight for Texas quarterback Quinn Ewers, a prospect huge on potential, but very short on experience. Now he lines up opposite Alabama ferocious front seven and playing behind an offensive line that far from proven. Ewers will make some good plays to Bijan Robinson and Xavier Worthy before the Tide finally settles in. ATS pick: Alabama by 24, covers the spreadArkansas State at No. 3 Ohio StatePoint spread: Ohio State -44. 5Arkansas State ATS: 1-0-0Ohio State ATS: 0-1-0What to expect: Not having Jaxon Smith-Njigba for a few weeks could hurt this offense, but CJ Stroud still has a room of other blue-chip receivers to work with, but a duo in the backfield of TreVeyon Henderson and Miyan Williams. Plus, the Buckeyes defense is coming off a great first impression after the game Jim Knowles called against Notre Dame. 44 Connor Meadows Jersey. 5 points is a lot, though. ATS pick: Ohio State by 42, doesnt cover spreadSouth Carolina at No. 16 ArkansasPoint spread: Arkansas -8. 5South Carolina ATS: 1-0-0Arkansas ATS: 1-0-0What to expect: Spencer Rattler can get the ball deep, but is coming off a debut where he threw 2 picks against Georgia State, and is working from behind a line that struggled. Arkansas packs a punch on the ground and has the back seven pieces to throw Rattler off his game. ATS pick: Arkansas by 10, covers the spreadAppalachian State at No. 6 Texas AMPoint spread: Texas AM -19App State ATS: 0-1-0Texas AM ATS: 0-1-0What to expect: The Mountaineers piled on 61 points against North Carolina, but dont expect that against the Aggies elite D. Haynes King had his ups and downs in the opener, throwing two long TD passes, but there were some timing issues with the O-line, and the ground game struggled. All those issues should solve themselves against an App State defense that was lost against the Tar Heels. ATS pick: Texas AM by 21, covers the spreadNo. 24 Tennessee at No. 17 PittsburghPoint spread: Tennessee -6Tennessee ATS: 1-0-0Pittsburgh ATS: 0-1-0What to expect: Pitt has a legit piece at quarterback with Kedon Slovis, who made most of the throws he had to last week, but he working from behind an offensive line that didnt fare well against West Virginia inexperienced pass rush. Tennessee can move the ball seemingly at will with dual threat quarterback Hendon Hooker behind the wheel. ATS pick: Tennessee by 7, covers the spreadNo. 20 Kentucky at No. 12 FloridaPoint spread: Florida -6Kentucky ATS: 1-0-0Florida ATS: 1-0-0What to expect: Kentucky likely wont have lead back Chris Rodriguez because of a suspension, which puts that much more pressure on Will Levis to win the game with his arm. He can do it, but the Gators have a weapon of their own: Anthony Richardson, the QB who played turnover-free football and ran for 3 TDs against a top 10 Utah team. ATS pick: Florida by 7, covers the spreadNo Addison Nichols Jersey. 9 Baylor at No. 21 BYUPoint spread: BYU -4Baylor ATS: 1-0-0BYU ATS: 1-0-0What to expect: Baylor won this one by 2 TDs a year ago, but the rematch promises to be closer. Both teams bring in stellar quarterbacks with deep range accuracy, agile receivers, and boast pristine offensive line protection. Combine two physical lines of scrimmage with a pair of promising backfields, and this one should come down to the 4th quarter. ATS pick: BYU by 3, doesnt cover the spread Other ATS college football picksSouthern Miss at No. 16 Miami. The Canes rushing attack helped put 70 on the board in the opener and should move with ease again here. Miami by 28, covers the spreadNo. 23 Wake Forestat Vanderbilt. Sam Hartman should be back in action after a medical scare to pick up where he left off leading college football 11th ranked offense. Wake by 14, covers the spreadMarshall at No. 8 Notre Dame. Marcus Freeman home opener should go as planned as the Irish develop this ground game and give Tyler Buchner more opportunities downfield that OSU didnt give him. Notre Dame by 22, covers the spread No William Wright Jersey. 25 Houston at Texas Tech. Tech lost quarterback Tyler Shough to injury, but Donovan Smith looked fine in reserve, throwing 4 TDs, while Houston played UTSA very close in the opener.